Is strong immunity the only reason? .. Reasons why some people never get infected with corona

The French newspaper “Le Figaro” said that some people, although not many, are less likely than others to contract Covid-19, despite their contact with people infected with the Corona virus, thanks to a set of very specific factors.

The newspaper explained – in a report By Mayle Aldebeer – 25-year-old Eloise (not her real name) has never had the disease, she says, wondering to herself, “I’ve been in contact with the disease several times, and my friend got it last summer, without paying any attention to it.” Her father also survived the injury, although he lived with his wife and two of his injured children in the same house.

The happy girl says with the strength of her immunity, without understanding why she and her father did not contract the virus, “We both did regular tests, and last July the serum test was negative, and we were vaccinated and we are dealing with the disease with caution, but nothing more.”

And the newspaper asked, why did some people never contract Covid-19 and never get infected with it, despite the continued rise of the “Omicron” wave and the records in France approaching half a million positive cases recorded within 24 hours? To be aware that Covid, like other diseases, has factors that increase the risks of its development, but also has factors that reduce them.

Professor of Public Health Philip Amuel says that “there are epidemiological studies to research the biological and morphological characteristics to see if these elements are associated with people who have never been infected,” including blood type, noting that there is consensus that people with type “or” ( O) Their risk of infection with Covid is less by about 20%, while it is higher for people with type “A” and “AB” (AB), says Jacques Lopando, director of research at the National Institute of Health and Medical Research at the University of Nantes.

And this researcher, who has collected dozens of studies published in this direction since the beginning of the epidemic, indicates that blood groups have a role at other levels in exposure to Covid-19, with better resistance for the owners of the type or the severity of the disease in particular.


The effectiveness of the immune system is another factor in reducing the risk of infection, and it varies for different people. “Some people get Covid less than others because of pre-existing immunity,” says Philip Amuel, who supervises a study at Imperial College that infection with group “A” viruses. Corona, which leads to the common cold, can confer immunity against infection with group B, which is the group of Covid-19.

In the study, the researchers concluded that having a cold can allow the body to manufacture T cells that are able to react more quickly with the SARS-CoV-2 virus that causes Covid-19, and this discovery It could be the basis for a new vaccine, in which T lymphocytes provide a more durable antibody response, unlike current vaccines that attack the spike protein that tends to mutate more easily, thus thwarting the current vaccine.

Is a booster dose of the COVID-19 vaccine effective?  Source: Hamad Medical Corporation in Qatar, Corona, infographic


In addition to blood type and immunity, another factor was found that reduces the risk of infection in the genetic aspect, as many studies have shown that genes have a strong role in the possibility of infection with a severe type of Covid-19, says Jean-François Deleuze, Director of the National Center for Human Genome Research that: “There are many reasons to believe that we could be more or less sensitive to infection due to a convergence of a virus and a receptor. At the genetic level we can imagine very specific differences in virus recognition that could prevent its entry.”

However, conducting a study to shed light on these peculiarities requires collecting a number of people who have never been infected with the Corona virus to expose them to the virus, and then measuring their antibody levels to look for genetic differences, but it is very difficult today to know whether a person is infected with the virus or not, especially Vaccination confers antibodies to a large majority of the population, and it is hard to imagine people voluntarily exposing them to COVID-19.

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